Relationship between the Course of the Disease and P300 of Patients with Closed Craniocerebral Trauma
Purpose: To probe into the relationship between the course of disease and the P300 of patients with closed craniocerebral trauma, and investigate the optimum time for P300 assay.
Methods: We used the medicid-03E brain evoked potential instrument of the Neuronic Company. The latency and the amplitude of P300 evoked by visual images were recorded in 518 patients with closed craniocerebral trauma. The findings from 385 abnormal cases were compared with those of 214 normal subjects and compared with the P300 during different conditions of injury and different times after injury.
Results: We found that the P300 latency in patient group was significantly prolonged as compared with the control group (p <0.001), and the amplitude was significantly decreased (p <0.01). The change of P300 was significant from 25h to 28h after injury, especially in patients with idiopathic coma. The abnormal level of P300 improved with the passage of time.
Conclusions: Therefore, the changes of P300 might be taken as an objective index of measuring the changes of brain cognition in patients with closed craniocerebral trauma, particularly in the period between 25h to 28h after injury. Besides, we believed that the extent of recovery of the patient's brain recognition function relates to the change of the latency and amplitude of P300. This may be used as the changes of P300 were useful and helpful for judging patient's condition and prognosis.
Key words: amplitude; brain; coma; cognition; craniocerebral trauma; evoked potentials; head trauma; latency; P300
Prehosp Disast Med 2001;16(2):s91.
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